MUMBAI, India, March 13 -- Intellectual Property India has published a patent application (202641025123 A) filed by Indian Institute Of Technology, Chennai, Tamil Nadu, on March 3, for 'a multilayer microfluidic platform for controlled isolation and concentration of cell-derived secretome.'

Inventor(s) include Santra, Tuhin Subhra; Rao, Suresh; R, Abinaya; and Krishnan, Lakshmi.

The application for the patent was published on March 13, under issue no. 11/2026.

According to the abstract released by the Intellectual Property India: "A multilayer microfluidic device for isolation of gingival cell-derived secretome is disclosed. The device comprises a plurality of stacked functional layers fabricated from a biocompatible material and forming a multilayer microfluidic chip. An inlet layer comprising a plurality of inlet ports is in fluid communication with a primary microchannel and is configured to introduce conditioned medium, a precipitating agent and a buffer solution. A micromixer region formed along the primary microchannel promotes controlled mixing, and a precipitation region disposed downstream permits formation of precipitated biomolecular aggregates under low-temperature conditions. A membrane support layer positioned downstream comprises a slot receiving a detachable membrane filter configured to separate precipitated particulates from soluble components. An outlet layer comprising at least one outlet channel is in fluid communication with the detachable membrane filter for recovery of processed fractions. The device is dimensioned to permit controlled flow and temperature-regulated precipitation within defined operational parameters."

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