MUMBAI, India, Nov. 21 -- Intellectual Property India has published a patent application (202431039253 A) filed by Dr. Biman B. Mandal; and Mr. Souradeep Dey, Guwahati, Assam, on May 20, 2024, for 'a microfluidic human physio-mimetic liver acinus model.'
Inventor(s) include Dr. Biman B. Mandal; and Mr. Souradeep Dey.
The application for the patent was published on Nov. 21, under issue no. 47/2025.
According to the abstract released by the Intellectual Property India: "The present invention discloses the development of a microfluidic based human physiomimetic liver acinus model as a drug screening platform. A liver extracellular matrix (ECM) mimetic biomaterial ink with high printing fidelity, tunable rheological and mechanical properties is formulated for supporting parenchymal and non-parenchymal cells. 3D printing and microfluidic technology is applied to bioengineer a human physiomimetic liver acinus model (HPLAM), recapitulating the radial hepatic cord-like structure with functional sinusoidal microvasculature network and physiological properties of native liver acinus. The hepatic cells incorporated HPLAM, acts as metabolic biofactories manifesting enhanced hepatic functionality, secretome levels and biomarkers expression over several weeks in culture. The matured HPLAM, in dynamic culture, reproduces dose- and time-dependent hepatotoxic response of human clinical relevance to drugs causing liver injury as compared to conventional static culture. The developed HPLAM would be a useful platform for drug development process and hepatotoxicity screening."
Disclaimer: Curated by HT Syndication.
