MUMBAI, India, April 17 -- Intellectual Property India has published a patent application (202511104957 A) filed by Post Graduate Institute Of Medical Education And Research, Chandigarh, India, on Oct. 30, 2025, for 'a method to develop immature neutrophil-like cells.'
Inventor(s) include Subhpreet Kaur; Uma Nahar Saikia; Parul Chawla Gupta; and Manni Luthra-Guptasarma.
The application for the patent was published on April 17, under issue no. 16/2026.
According to the abstract released by the Intellectual Property India: "The present invention discloses a novel method for differentiating HL-60 promyelocytic leukemia cells into immature neutrophil-like cells exhibiting anti-inflammatory and alternatively activated phenotypes. The differentiated cells display characteristic morphological features including band-shaped nuclei and reduced nuclear to cytoplasmic ratios, along with elevated reactive oxygen species production upon stimulation. Furthermore, these cells express increased levels of immature neutrophil surface markers (CD11b, CD14) and immunomodulatory molecules such as arginase 1, transforming growth factor-beta 1, with decreased expression of the M2 macrophage marker. The method overcomes limitations associated with scarce availability and culturing challenges of primary immature neutrophils, providing a reproducible and scalable in vitro platform for immunological research, drug screening, and development of targeted immunotherapies. The invention thus offers significant advancement in modeling neutrophil heterogeneity and immune regulation with potential applications in infectious, inflammatory, cancer, and autoimmune disease studies."
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