MUMBAI, India, Feb. 6 -- Intellectual Property India has published a patent application (202541085234 A) filed by Chalapathi Institute Of Pharmaceutical Sciences, Guntur, Andhra Pradesh, on Sept. 8, 2025, for 'a method of synthesizing oxazepine based compounds.'
Inventor(s) include Rama Rao Nadendla; and Aneesha Addanki.
The application for the patent was published on Feb. 6, under issue no. 06/2026.
According to the abstract released by the Intellectual Property India: "The present disclosure proposes a method of synthesizing oxazepine based compounds possessing potent inhibitory activity against the acetylcholinesterase (AChE) enzyme, thereby serving as effective therapeutic agents for the prevention of Alzheimer's disease. Initially, an aldehyde derivative (2a-2l) and anthranilic acid (1) are dissolved in ethanol, thereby promoting a reaction that results in the formation of a Schiff base (3a-3l). Next, the Schiff base (3a-3l) is dissolved with plurality of anhydrides includes phthalic (4), maleic (5), and succinic anhydride (6) in the presence of a solvent and catalyst, thereby facilitating a reaction that yields plurality of ligands ((7a-7l), (8a-8l), (9a-9l)). Finally, the oxazepine based compounds (8d, 9c) are isolated from the plurality of ligands ((7a-7l), (8a-8l), (9a-9l)) and the oxazepine based compounds (8d, 9c) is subjected to purification. The proposed oxazepine compounds (8d, 9c) enhances cognitive performance, memory retention, and quality of life."
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