MUMBAI, India, Jan. 23 -- Intellectual Property India has published a patent application (202511123908 A) filed by Noida Institute Of Engineering & Technology, Greater Noida, Uttar Pradesh, on Dec. 9, 2025, for 'a method for synthesis, in-silico screening, and in-vivo evaluation of diuretic potential of 1,3,4-oxadiazoles.'
Inventor(s) include Dr Rajnish Kumar; Dr Salahuddin; Upasana Sharma; Dr Rakhi Mishra; Ms Shrishti Tripathi; and Mr Anmol Dogra.
The application for the patent was published on Jan. 23, under issue no. 04/2026.
According to the abstract released by the Intellectual Property India: "Disclosed herein is a method (100) is disclosed for synthesis, in-silico screening, and in-vivo evaluation of 1,3,4-oxadiazoles bearing piperazine and naphthalene moieties. The process begins with synthesizing 2-chloro-1-(piperazin-1-yl) ethan-1-one derivatives (102) by refluxing bis-chloroethylamine with aniline derivatives in butanol. Subsequently, 5-(naphthalen-1-ylmethyl)-1,3,4-oxadiazole-2-thiol (104) is prepared via esterification of naphthoxyacetic acid in ethanol using concentrated sulfuric acid. These intermediates are further reacted to synthesize 2-((5-(naphthalen-2-ylmethyl)-1,3,4-oxadiazol-2-yl) thio)-1-(piperazin-1-yl) ethan-1-one derivatives (106) in acetone under reflux with potassium carbonate. The resulting compounds undergo characterization (108) using advanced analytical instruments to confirm purity and structure."
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