MUMBAI, India, July 11 -- Intellectual Property India has published a patent application (202541054025 A) filed by Manipal Academy Of Higher Education, Manipal, Karnataka, on June 4, for 'a method for quantifying lumefantrine from carbon dot-based nanoformulation using high-performance liquid chromatography.'
Inventor(s) include Raksha J; Aditya Dev Rajora; Ashutosh Gupta; Sudheer Moorkoth; Moumita Saha; and Abhay Bhardwaj.
The application for the patent was published on July 11, under issue no. 28/2025.
According to the abstract released by the Intellectual Property India: "The present invention relates to a validated RP-HPLC method for quantifying lumefantrine (LUM) from carbon dot (CD)-based nanocarriers designed to enhance solubility and bioavailability in malaria treatment. The method, optimized using Box-Behnken Design under a Design of Experiments (DoE) framework, enables accurate evaluation of drug entrapment efficiency, loading capacity, in-vitro release, and stability. It demonstrates high linearity (R > 0.999), precision (%CV < 2%), and eco-friendliness (AGREE score: 0.7). The invention also includes a microwave-assisted synthesis protocol for CDs using citric acid and urea, with optimized LUM loading yielding 65.19% entrapment and 18.23% loading. The method facilitates reliable analysis of LUM under various pH and degradation conditions, supporting sustainable development and quality control of nanoparticle-based antimalarial formulations."
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