MUMBAI, India, Aug. 22 -- Intellectual Property India has published a patent application (202411009623 A) filed by Amity University, Noida, Uttar Pradesh, on Feb. 12, 2024, for 'a method for providing biotransformation of vinblastine into vincristine using an endophyte fusarium equiseti.'
Inventor(s) include Gauri Srivastava; and Deepak Ganjewala.
The application for the patent was published on Aug. 22, under issue no. 34/2025.
According to the abstract released by the Intellectual Property India: "The present invention discloses a method for providing Biotransformation of vinblastine into vincristine using an endophyte Fusarium equiseti. In the present invention, biotransformation is conducted in a 500 ml conical flask filled with 100 ml PDB inoculated with the microbes and incubated for 10 days at 25-30 C. Further, the parameters are optimized such as the pH, rotation speed, substrate, and culture concentrations to enhance the efficiency of the biotransformation system. The results of LC/MS analyses showed that only F. equiseti was capable of catalyzing the biotransformation of vinblastine into vincristine. After 8 days of incubation with F. equiseti, approximately 42% of vinblastine was biotransformed into vincristine. It is found that vincristine was produced with all parameters tested, but the most favourable conditions for its production were pH 5.6, rotation speed 200 rpm, vinblastine (25 l), and culture (150 l) with an incubation period of 8 days at 30 C."
Disclaimer: Curated by HT Syndication.
