MUMBAI, India, May 1 -- Intellectual Property India has published a patent application (202641050258 A) filed by Anurag University, Hyderabad, Telangana, on April 20, for 'a method for preparing sustained release microspheres of losartan potassium for hypertension therapy.'
Inventor(s) include Dr. Dibyalochan Mohanty; Dr. Swapna. S; D. Pavan Kumar; and Madduluri Shiva Kailash.
The application for the patent was published on May 1, under issue no. 18/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a method (100) for preparing sustained-release microspheres of Losartan potassium (102) using an emulsion solvent evaporation technique (108). The method comprises dissolving Losartan potassium (102) and one or more release-modifying polymers in an organic solvent to form a homogeneous drug polymer solution (104). The solution is dispersed into a continuous oil phase comprising coconut oil and an emulsifier such as Span-80 under controlled stirring (106) to form a stable emulsion. The emulsion is stirred for 2 to 3 hours to allow solvent evaporation and formation of solidified microspheres (108). The microspheres are collected by vacuum filtration (110), washed with a non-polar solvent such as n-hexane (112) to remove residual oil, and dried in a desiccator or equivalent unit (114). The resulting microspheres exhibit uniform particle size, high drug entrapment efficiency, and sustained release of Losartan potassium for up to 10 hours, improving bioavailability, therapeutic efficacy, and patient compliance in hypertension management."
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