MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202641007472 A) filed by Vellore Institute Of Technology, Vellore, Tamil Nadu, on Jan. 26, for 'a method for modulating gpr10 using small molecule ligands.'
Inventor(s) include Dr. Sudandiradoss C; Manshi Kumari Gupta; and Pranjali Dutta.
The application for the patent was published on Feb. 13, under issue no. 07/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a computer-implemented, structure-guided method for identifying and evaluating a ligand-interaction site on G-protein-coupled receptor 10 (GPR10). The method comprises selecting GPR10 based on tissue-specific expression relevance, generating and stereochemically validating a three-dimensional receptor model, and preparing small-molecule ligands through geometry optimization and energy minimization. Molecular docking is performed across multiple predicted binding cavities of GPR10, followed by comparative analysis to identify a preferred ligand-accessible interaction region based on binding affinity, pocket occupancy, and interaction consistency. Stability and persistence of ligand engagement at the identified interaction region are validated using molecular dynamics simulations under simulated physiological conditions. The invention further integrates in-silico molecular property evaluation to support ligand interaction analysis. The disclosed framework provides a reproducible computational approach for receptor-site identification and small-molecule interaction evaluation without involving therapeutic treatment or clinical intervention steps."
Disclaimer: Curated by HT Syndication.
