MUMBAI, India, April 10 -- Intellectual Property India has published a patent application (202411066594 A) filed by Amity University, Noida, Uttar Pradesh, on Sept. 3, 2024, for 'a method for mitigating cognitive impairment from sleep deprivation via glutamate regulation.'
Inventor(s) include Vivek Srivastava; and Sharvari Nikhil Bhat.
The application for the patent was published on April 10, under issue no. 15/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a method for mitigating cognitive impairment resulting from chronic sleep deprivation through modulation of glutamate neurotransmission. Sleep deprivation disrupts glutamate balance, impairs synaptic plasticity, and induces oxidative stress, leading to cognitive dysfunction similar to dementia. The method comprises administering acetyl L-carnitine (ALC), alone or in combination with memantine hydrochloride or glutamic acid, at defined therapeutic doses prior to induction of sleep deprivation. In animal models, ALC administration significantly reduced malondialdehyde (MDA) levels, increased glutathione (GSH) concentration, restored hippocampal and cerebral neuronal integrity, and improved behavioral outcomes in Morris water maze and novel object recognition tests. Combination therapy with memantine enhanced NMDA receptor modulation and provided synergistic effects in restoring excitatory-inhibitory neurotransmission. The invention further provides pharmaceutical compositions comprising ALC with pharmaceutically acceptable carriers for oral, injectable, or intraperitoneal delivery."
Disclaimer: Curated by HT Syndication.
