MUMBAI, India, April 10 -- Intellectual Property India has published a patent application (202411070576 A) filed by Amity University, Noida, Uttar Pradesh, on Sept. 18, 2024, for 'a method for extraction and bioactivity analysis of c. infortunatum linn.'
Inventor(s) include Nidhi Srivastava; and Seema Bhatnagar.
The application for the patent was published on April 10, under issue no. 15/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a method for the extraction and bioactivity analysis of Clerodendrum infortunatum Linn. with particular emphasis on its antiangiogenic properties. The method involves collection, authentication, drying, and pulverization of plant roots, followed by methanolic extraction 7 and sequential polarity-based fractionation using hexane, chloroform, ethyl acetate, and methanol. Phytochemical screening and instrumental analyses including GC-MS, LC-MS, and NMR confirmed the presence of bioactive compounds such as scutellarin, baicalin, wogonoside, cornuside, acacetin, datiscin, and (+)-pinoresinol. Bioactivity was validated using Chorioallantoic Membrane (CAM) assay, MTT cell viability assay on Panc-1 and MiaPaCa-2 pancreatic cancer cell lines, and scratch wound healing assay, with the 14 ethyl acetate fraction demonstrating maximum antiangiogenic and anticancer potential. Molecular docking studies further supported binding affinities of key compounds with angiogenesis-related proteins. The invention provides a reproducible and efficient method for isolating potent plant-derived compounds, enabling development of natural therapeutic alternatives for cancer and angiogenesis-associated disorders."
Disclaimer: Curated by HT Syndication.
