MUMBAI, India, Jan. 23 -- Intellectual Property India has published a patent application (202511123853 A) filed by Noida Institute Of Engineering & Technology, Greater Noida, Uttar Pradesh, on Dec. 9, 2025, for 'a method for evaluation of substituted phenyl-urea derivatives.'
Inventor(s) include Dr Rakhi Mishra; Dr Avijit Mazumder; Ms Janvi Rohella; Shruti Varshney; and Bhavani Pentela.
The application for the patent was published on Jan. 23, under issue no. 04/2026.
According to the abstract released by the Intellectual Property India: "Disclosed herein is a method for synthesis, characterization, and anticonvulsant activity evaluation of novel substituted phenyl-urea derivatives (100) involves synthesizing benzenecarbonyl chloride (102) by reacting benzoic acid with a chlorinating agent, followed by preparing benzenecarboxamide (104) through reaction with an amine in a suitable solvent. The amide compound is converted to phenyl isocyanate (106) via dehydration, which is then reacted with various substituted amines to yield substituted phenyl-urea derivatives (108). The derivatives are purified using chromatographic techniques (110) and characterized (112) by melting point determination and spectroscopic analysis. In-silico molecular docking (114) is conducted to assess receptor binding, while ADME profiling (116) evaluates pharmacokinetic properties. Acute toxicity studies (118) determine safety levels, and anticonvulsant activity (120) is assessed using established seizure models to identify compounds with significant therapeutic potential."
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