MUMBAI, India, May 1 -- Intellectual Property India has published a patent application (202611025969 A) filed by Noida Institute Of Engineering & Technology, Greater Noida, Uttar Pradesh, on March 5, for 'a method for design, synthesis, and biological evaluation of novel thiazole derivatives as antidiabetic agents.'
Inventor(s) include Dr Chandana Majee; Ms Dimple; Dr Avijit Mazumder; Dr Saumya Das; Mr Anmol Dogra; and Mr Himanshu Singh.
The application for the patent was published on May 1, under issue no. 18/2026.
According to the abstract released by the Intellectual Property India: "Disclosed herein is a method (100) for design, synthesis, and biological evaluation of novel thiazole derivatives as antidiabetic agents comprises designing thiazole derivative analogues (102). The method (100) includes synthesizing the designed thiazole derivatives (104), which is further converted (106) into a series of thiazole acetamide and benzamide derivatives. The synthesized derivatives are purified (108) by filtration, recrystallization, and thin layer chromatography using silica gel and selected solvent systems as a mobile phase, and characterized (110) by determining melting point, infrared spectra, proton nuclear magnetic resonance spectra, carbon-13 nuclear magnetic resonance spectra, mass spectra, and elemental analysis. The method (100) further involves determining physicochemical and drug-likeness parameters (112) to biological evaluation for antidiabetic activity (114) in a streptozotocin-induced diabetic model (116), administering the derivatives at predetermined doses (118) and comparing them with a standard antidiabetic drug, performing acute toxicity studies (120), and analyzing biological data (122)."
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