MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202611050885 A) filed by Swami Vivekanand Subharti University; and Dr. Nisha Rana, Meerut, Uttar Pradesh, on April 21, for 'a method, a wearable dermal bioreactor device, and a system for programmable quorum-stabilized and threshold-encoded biomarker detection using engineered skin bacteria.'

Inventor(s) include Dr. Nisha Rana; and Professor Dr. Anjali Khare.

The application for the patent was published on May 29, under issue no. 22/2026.

According to the abstract released by the Intellectual Property India: "The present invention discloses a wearable dermal bioreactor system for non-invasive physiological biomarker monitoring using engineered commensal skin bacteria configured as a programmable biological computing platform. The system comprises a dermal containment matrix, a microfluidic diffusion interface for controlled biomarker transport, and genetically engineered microbial chassis incorporating synthetic genetic circuits. The circuits perform threshold-encoded detection, baseline-adaptive comparison, time-integrated evaluation, and quorum-stabilized population-level synchronization prior to generating a visually perceptible output indicative of biomarker magnitude and persistence. A visual reporting interface produces chromogenic or fluorescent signals that are directly observable without reliance on electronic sensing hardware. Optional optical capture enables digital quantification and longitudinal trend analysis. The dermal bioreactor architecture further incorporates biosafety containment mechanisms to ensure controlled microbial activity under physiological conditions."

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