MUMBAI, India, July 25 -- Intellectual Property India has published a patent application (202411002196 A) filed by Amity University, Noida, Uttar Pradesh, on Jan. 11, 2024, for 'a magnetic resonance imaging (mri) contrast agent based on a bimetallic porous coordination polymer (pcp) and preparation method thereof.'
Inventor(s) include Karan Hadwani; Chansi; Rashi Bhardwaj; and Tinku Basu.
The application for the patent was published on July 25, under issue no. 30/2025.
According to the abstract released by the Intellectual Property India: "The present invention discloses a Next-generation MRI contrast agent: A bimetallic porous coordination polymer and preparation method thereof. In the present invention, which elucidates a new and advantageous magnetic resonance imaging (MRI) contrast agent based on a porous coordination polymer (PCP). The PCP gets smaller in size, having an average diameter of 27.5 nm which allows better tissue penetration and lesser side effects. The material turns from ferromagnetic to paramagnetic after addition of second metal, this property is important for MRI applications as it enables imaging of soft tissues. The PCP based MR contrast agent has both T1 and T2 relaxation (6.03 mM-1 s-1 and 53.65 mM-1 s-1) making it a dual-contrast MRI agent allowing both positive and negative contrast. Additionally, PCP was stabilized using a biosafe layer, which will allow for adequate circulation time and complete clearance after imaging."
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