MUMBAI, India, Feb. 6 -- Intellectual Property India has published a patent application (202541090442 A) filed by Manipal Academy Of Higher Education, Manipal, Karnataka, on Sept. 22, 2025, for 'a composition for biocompatible reversible sacrificial hydrogel and a method thereof.'
Inventor(s) include Mathew Peter; Joyline Prathiksha; Rudra Nath Ghosh; Pramod K; and Joseph Thomas.
The application for the patent was published on Feb. 6, under issue no. 06/2026.
According to the abstract released by the Intellectual Property India: "This invention pertains to a hydrogel composition that is biocompatible and can be reversibly crosslinked, consisting of oxidized alginate (OA), gelatin, and borax, intended for application as a sacrificial material in 3D bioprinting and tissue engineering. The hydrogel is created through ionic crosslinking of OA and gelatin with 0.1 M borax, allowing gentle gelation and later elimination under physiological conditions like exposure to phosphate-buffered saline at 37 C. This structure offers temporary support during production and aids in developing internal voids or vascular-like pathways in a lasting scaffold. The formulation can be adjusted in degradation speed through pH and temperature, maintaining excellent structural integrity after removal. The hydrogel lacks harmful photoinitiators, accommodates cell-loaded structures, and is ideal for extrusion printing. It is adaptable, economical, and eco-friendly, providing a flexible option for bio-fabrication, organ-on-chip systems, and surgical modeling that needs temporary, biodegradable internal structures."
Disclaimer: Curated by HT Syndication.
