MUMBAI, India, Feb. 6 -- Intellectual Property India has published a patent application (202541090425 A) filed by Manipal Academy Of Higher Education, Manipal, Karnataka, on Sept. 22, 2025, for 'a composition and method for fabricating perfusable tissue constructs using dual-hydrogel bioprinting systems.'
Inventor(s) include Mathew Peter; Joyline Prathiksha; Akshatha; Rudra Nath Ghosh; Pramod K; and Joseph Thomas.
The application for the patent was published on Feb. 6, under issue no. 06/2026.
According to the abstract released by the Intellectual Property India: "The current invention pertains to a dual-hydrogel formulation and a technique for creating perfusable hollow tissue structures through a combined bioprinting method. The system consists of a hydrogel matrix that includes methacrylate-functionalized gelatin (GelMA) and thiolated gelatin (Gel-SH), which are crosslinked using UV light and thiol-ene chemistry to create a scaffold that is both biocompatible and mechanically stable. A sacrificial hydrogel made of gelatin and oxidized alginate, crosslinked by borax, is co-printed to create temporary internal channels. These pathways are intentionally eliminated under gentle aqueous conditions, leading to open, flow-capable networks that resemble natural blood vessels. The technique ensures high cell viability, customizable shapes, and regulated mechanical attributes, making it appropriate for tissue engineering, organ-on-chip systems, and drug testing purposes. This innovation allows for scalable, high-precision creation of vascularized structures that could be used in regenerative medicine, disease modeling, and soft lithography."
Disclaimer: Curated by HT Syndication.
