MUMBAI, India, June 30 -- Intellectual Property India has published a patent application (202641073848 A) filed by Vellore Institute Of Technology on June 15, 2026, for “a Novel Peptide Vmne244 From Lactobacillus Acidophilus Membrane Vesicles: Synthesis And Antibacterial Activity Against Streptococcus Mutans”.
Inventors include Nalini E; and Venkatramanan Mahendrarajan.
The application for the patent was published on June 26, 2026, under issue no. 26/2026.
Abstract: The present invention relates to Synthetic Antibacterial Peptide VMNE244 Derived from Lactobacillus acidophilus Membrane Vesicles, comprises the amino acid sequence KAVREIIRYMKK (SEQ ID NO: 1), characterized by a molecular weight of approximately 1534.93 Da, a net positive charge of +4, and defined physicochemical properties including a high isoelectric point and hydrophobic moment. The peptide is naturally associated with membrane vesicles derived from Lactobacillus acidophilus (MTCC 10307) and is identified through a proteomic workflow involving liquid chromatography–tandem mass spectrometry, high- confidence peptide validation, and in silico antimicrobial screening. The disclosure further provides a method for identifying antibacterial peptides from probiotic bacterial membrane vesicles based on physicochemical selection criteria, enabling the identification of VMNE244 as a potent antimicrobial agent with activity against oral cariogenic pathogens. Fig 1 to 8.
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