MUMBAI, India, June 30 -- Intellectual Property India has published a patent application (202641074774 A) filed by Vellore Institute Of Technology on June 17, 2026, for “a Dual-Drug Loaded Nanoemulsion Composition For Topical Management Of Infected Wounds”.
Inventors include Dr. Natarajan Chandrasekaran; Dr. George Priya Doss C; Mr. Mohanraj Gopikrishnan; and Ms. Prathiksha Vasudev.
The application for the patent was published on June 26, 2026, under issue no. 26/2026.
Abstract: The present invention relates to a dual-drug loaded nanoemulsion composition and method for topical management of infected wounds. The composition comprises cinnamaldehyde as an oil phase, rifampicin as a lipophilic antibiotic incorporated within the oil phase, vancomycin as a hydrophilic antibiotic distributed within an aqueous phase, a surfactant system comprising Tween 80, a co-surfactant selected from ethanol, propylene glycol, or combinations thereof, and water. The cinnamaldehyde functions both as a bioactive antimicrobial agent and as a nanoemulsion-forming carrier matrix, thereby enabling simultaneous encapsulation and delivery of hydrophilic and lipophilic antibiotics within a single nanoemulsion platform. The nanoemulsion is formulated as a sprayable dispersion having nanoscale droplet size and phase-specific drug localization, wherein rifampicin is retained within the oil phase and vancomycin is distributed within the aqueous phase. Upon topical administration, the nanoemulsion provides uniform coverage of infected wound surfaces and facilitates enhanced penetration into microbial biofilms and infected tissues. The composition exhibits a multi-target antimicrobial mechanism comprising bacterial membrane disruption by cinnamaldehyde, inhibition of bacterial RNA transcription by rifampicin, and inhibition of bacterial cell wall synthesis by vancomycin, thereby providing synergistic antibacterial activity against drug-resistant microorganisms including methicillin-resistant Staphylococcus aureus (MRSA). The invention enables localized antimicrobial therapy, enhanced tissue penetration, reduced systemic exposure, improved wound healing, and elimination of secondary delivery systems such as hydrogels, dressings, scaffolds, or polymeric carriers. Fig 1 to 3.
Disclaimer: Curated by HT Syndication.
